Market Size & Trends

The global downstream processing market size was estimated at USD 30.96 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 14.84% from 2023 to 2030. A rise in the utilization of downstream processing techniques for the development of COVID-19 vaccines is a significant factor driving the market. In March 2022, Rentschler Biopharma and Vetter released the launch of Xpert Alliance, a collaborative representation of their strategic relationship. The visualization is intended to "bring to life" this continuing collaboration and highlight its successful operation in offering effective solutions to customers' evolving and growing demands in the field of challenging biopharmaceuticals.

Further, in April 2022, Bayer revealed that it is considering a collaboration wherein Ginkgo Bioworks will purchase Bayer's West Sacramento Biologics R&D location as well as its internal discovery and lead optimization platform. The deal will allow Bayer to improve its leadership position in biologicals, gain access to critical supporting technologies in synthetic biology, and preserve Bayer's position as the preferred biologics research, development, and commercial partner.

Gather more insights about the market drivers, restrains and growth of the Global Downstream Processing Market

Products Insights

The chromatography systems segment dominated the market for downstream processing and accounted for the largest revenue share of 41.29% in 2022. Continuous R&D to improve the efficiency and speed of chromatography systems is anticipated to propel the segment growth. In April 2021, Thermo Fisher Scientific launched the HyPeak chromatography system, its company's only single-use chromatography system for bioprocessing, with significant functions in therapeutic protein as well as vaccine development. 

Technique Insights

The purification by chromatography segment dominated the downstream processing market and accounted for the largest revenue share of 40.98% in 2022. Single-use chromatography and filtration systems are considered the gold standards in downstream bioprocessing, hence companies are engaging in business development strategies such as acquisition, merger, and agreement for expanding their chromatography portfolio.

Application Insights

The antibiotic production segment dominated the market for downstream processing and generated the largest revenue share of 32.48% in 2022 owing to the wide applications of antibiotics for the treatment of several disorders. More than 700,000 people die of antibiotic-resistant bacteria annually. This leads to high demand for the development of antibiotics which, in turn, propels the market growth.

Regional Insights

North America dominated the market for downstream processing with the largest revenue share of 34.57% in 2022 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure. In addition, the region has witnessed major collaborative activities with healthcare giants that are extensively investing in the R&D of biopharmaceuticals and vaccines. In addition, key players operating in the market for downstream processing are expanding their foothold in this region.

Key Companies & Market Share Insights

Companies are increasingly focusing on the development of new products for downstream processing. For instance, in February 2022, Sartorius completed its purchase of Novasep's chromatography section. The portfolio bought includes chromatography systems designed largely for smaller biomolecules like peptides, oligonucleotides, and insulin, as well as new technologies for biologics' continuous production. Furthermore, in January 2023, the company collaborated with RoosterBio Inc. to enhance its downstream purification processes for exosome-based therapies.

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Some of the prominent players in the downstream processing market include:

• Merck KGaA
• Sartorius Stedim Biotech S.A
• GE Healthcare
• Thermo Fisher Scientific Inc.
• Danaher Corporation
• Repligen
• 3M Company
• Boehringer Ingelheim International GmbH
• Corning Corporation
• Lonza Group Ltd
• Dover Corporation
• Ashai Kasei
• Ferner PLC

• Eppendorf AG

Downstream Processing Market Segmentation

Grand View Research has segmented the global downstream processing market based on product, technique, application, and region:

Downstream Processing Product Outlook (Revenue, USD Billion, 2018 - 2030)

• Chromatography Systems
• Filters
• Evaporators
• Centrifuges
• Dryers
• Others

Downstream Processing Technique Outlook (Revenue, USD Billion, 2018 - 2030)

• Cell Disruption
• Solid-liquid separation
• Concentration
• Purification by Chromatography
• Formulation

Downstream Processing Application Outlook (Revenue, USD Billion, 2018 - 2030)

• Antibiotic Production
• Hormone Production
• Antibodies Production
• Enzyme Production
• Vaccine Production

Downstream Processing Regional Outlook (Revenue, USD Billion, 2018 - 2030)

• North America
• U.S.
• Canada
• Europe
• Germany
• U.K.
• France
• Italy
• Spain
• Denmark
• Sweden
• Norway
• Asia Pacific
• Japan
• China
• India
• South Korea
• Thailand
• Australia
• Latin America
• Brazil
• Mexico
• Argentina
• Middle East and Africa (MEA)
• South Africa
• Saudi Arabia
• UAE
• Kuwait

Order a free sample PDF of the Downstream Processing Market Intelligence Study, published by Grand View Research.

About Grand View Research

Grand View Research is a full-time market research and consulting company registered in San Francisco, California. The company fully offers market reports, both customized and syndicates, based on intense data analysis. It also offers consulting services to business communities and academic institutions and helps them understand the global and business scenario to a significant extent. The company operates across multitude of domains such as Chemicals, Materials, Food and Beverages, Consumer Goods, Healthcare, and Information Technology to offer consulting services.

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